The results from MMTV-PyVT mice show that TPPP3+ monocytes, ISG15+ macrophages, IFIT3+ neutrophils, and IL12B+ DCs are mainly present in the tumor-reprogrammed lung microenvironment, and the metastasis-associated myeloid subpopulations are validated at the protein level. This evidence concerns the gene IFIT3 and neoplasm.