ISG15 and neoplasm: Then, we performed immunofluorescence staining on the normal lung, primary tumor, and metastatic lung sections using the markers of Tppp3+ monocytes (LY6C and TPPP3), Isg15+ macrophages (F4/80 and ISG15), Ifit3+ neutrophils (MPO and IFIT3), and Il12b+ DCs (CD11c and IL12B) (Figure 6C).