However, since IL-17A/F cytokines were not important for host survival herein, and γδ T cells produce IL-17 cytokines in response to IL-1R signaling (42), it begs the question of how γδ T cell-intrinsic IL-1R signaling is mediating protection against S. aureus bacteremia? The gene discussed is IL1R1; the disease is bacterial infectious disease with sepsis.