Th1 cytokines drive oxidative stress and cause a significant decrease in SIRT1 expression associated with HIF-1α, GLUT-1, and VEGF-A upregulation, suggesting that SIRT1 (a key regulator of oxidative stress) may be regarded as a potential therapeutic target for Hashimoto’s thyroiditis (63). This evidence concerns the gene SIRT1 and Hashimoto thyroiditis.