SIRT1 and ulcerative colitis: used the SIRT1 activator SRT1720 to reduce intestinal epithelial cell apoptosis in ulcerative colitis via inhibition of CHOP and cystein-12 (molecules associated with endoplasmic reticulum stress-mediated apoptosis); in contrast, administration of nicotinamide (a SIRT1 inhibitor) exerted the opposite effect (84).