In summary, an effective way to slow the progression of RA is to promote apoptosis, inhibit FLS proliferation, invasion and migration, and suppress synovial inflammation.SIRT1 produces negative regulatory effects on various pathways, mainly targeting FLS, while also improving the function of other immune cells, such as M1/M2 phenotype switching, to exert an inhibitory effect on inflammation. The gene discussed is SIRT1; the disease is rheumatoid arthritis.