Additionally, resveratrol treatment had been shown to significantly improve DSS-induced colitis and restore the SIRT1-mRNA levels (85), to upregulate the expression of phosphorylated mammalian target of rapamycin (mTOR) and SIRT1 in colonic tissues, to reduce autophagy, and to regulate SIRT1/mTOR signalling via inhibition of the intestinal inflammatory cascade response (86). Here, SIRT1 is linked to colitis.