Surprisingly, in some cases, SIRT1 activation also alleviates renal damage in SLE, and RSV has been found to reduce proteinuria and immunoglobulin deposition in lupus nephritis and IgG1 and IgG2a levels in the serum of pristane-induced lupus mice by activating SIRT1 (131). The gene discussed is SIRT1; the disease is systemic lupus erythematosus.