Hyperglycemia leading to the activation of alternative pathways of glucose metabolism (Polyol, PARP, protein kinase C, hedgehog and more) leads to the formation of AGEs, ROS, lipooxygenase pathways (LOX) and an elevation of proinflammatory cytokines (IL-6 and TNFɑ) (97) (Figure 5). The gene discussed is TNF; the disease is Hyperglycemia.