KLRK1 and neoplasm: As shown in Figure 3, BVE-Ctnnb1null cells showed up-regulation of NKG2D activating ligands (H60a, H60b, H60c, Raet1a, Raet1b, Raet1c, Raet1d, Raet1e and Ulbp1) and down-regulation of inhibitory MHC class I molecules (H2-L, H2-K2, and H2-D1), which may lead to NK cell activation and tumor cell clearance.