The genes typically involved in cancer growth and progression, such as extracellular matrix organization, chemotaxis, vascular development, integrin cell surface interactions and signaling, and ERK-1/ERK2 signaling, were among the top 20 enriched ontology clusters that were significantly down-regulated in the BVE-Ctnnb1null cells (Figure 2B). This evidence concerns the gene MAPK3 and cancer.