The median age was 53 years (interquartile range, 46.0-58.0), and 78 patients (85.7%) were HBsAg-positive, 52 patients (57.1%) had liver cirrhosis, nearly all patients were in Child-Pugh class A, and only three patients (3.3%) in Child-Pugh class B. Tumor markers showed 64 patients (70.3%) to have AFP levels above 20μ g/L, and 76 patients (83.5%) had elevated PIVKA-II levels. This evidence concerns the gene AFP and cirrhosis of liver.