Melanoma differentiation-associated gene 5 (MDA5) senses the accumulation of dsRNA, which is similar to a viral infection (viral mimicry), this leads to activation of innate antiviral pathways, resulting in the production of type I and type III interferon (IFN) as well as the processing and presentation of antigens (23, 26, 27). This evidence concerns the gene IFIH1 and viral infectious disease.