observed that LSD1 suppression promoted catalase expression during M1 polarization, which in turn inhibited the expression of pro-inflammatory cytokines and M1-related surface markers (such as CD14, TNF-α, COX2, IL1-β, IFNAR, and TLR2), which suggested that LSD1 inhibition can limit the macrophage M1 specialization in the non-tumor tissues (56). This evidence concerns the gene KDM1A and neoplasm.