Mechanistically, LSD1 blockade increases the enrichment of H3K4me2 at proximal elements or core regions of the transcription start site of CD8+ T cell-attracting chemokine promoters, which induces the expression of CD8+ T cell-attracting chemokines (CCL5, CXCL9, CXCL10), thereby promoting the infiltration of CD8+ T cell into tumor tissues and exerting tumor-killing effects (40). This evidence concerns the gene CD8A and neoplasm.