SOX2 and lung adenocarcinoma: Indeed, Sox2 amplification or overexpression is a frequently occurring event, for example in Breast, Colorectal, Esophageal, Liver, Lung adenocarcinoma, Prostate and is associated with advanced stages of tumorigenesis, poor prognosis, and drug resistance, making Sox2 a target for anti-cancer therapies (82, 83).