After establishing that NK cells exhibit enhanced cytotoxicity against SARS-CoV-2 infected Caco-2 cells as opposed to non-infected cells, we assessed if blockade of NKG2A, KIR2DL1 or a combination can enhance the NK cell-mediated cytotoxicity using blocking antibodies (n=3 COVID-19 positive donors). Here, KIR2DL1 is linked to COVID-19.