For example, CXCR4-targeted lipid-coated PLGA NPs with sorafenib and AMD3100 (a CXCR4 antagonist) revealed that blocking the interaction of TAM CXCR4 with SDF1α reduced M2-like macrophage polarization and TAMs infiltration, and simultaneously tumor progression was delayed in a mouse model of HCC (208). This evidence concerns the gene CXCR4 and hepatocellular carcinoma.