Firstly, we illustrated the distribution feature of previously reported six pan-cancer immune subtypes (C1-C6) (30), of which LMS1 and LMS2 were mostly clustered into C1 (Wound Healing), C2 (IFN-γ Dominant), C3 (Inflammatory), C4 (Lymphocyte Depleted) and C6 (TGF-β Dominant) (Supplementary Figure 2B). Here, TGFB1 is linked to cancer.