NK cells, γδ T cells and neutrophils play a critical role in the disease, alongside Th1/Th2/T17 dysregulation and a decrease in T reg cells (82, 88) Cytokine studies have demonstrated elevated levels of TNF-α in Behçet’s disease, with a positive correlation between TNF-α levels and disease activity (82). Here, TNF is linked to Behcet disease.