In a sample of 61 MCI patients, the relationship of distant Aβ -cortical thinning was also reported in other DMN regions.10 Given the variability in clinical subtypes and disease progression, future research integrating Aβ PET, tau PET imaging, and diffusion weighted imaging (DWI) in larger samples of MCI patients will allow for additional fine-grained investigation into the pathological drivers underpinning brain atrophy during the prodromal phases. Here, MAPT is linked to Brain atrophy.