Previous research has demonstrated the distant effects of Aβ on neurodegeneration in AD.45,46 For instance, Aβ in frontal regions (as well as temporal and parietal regions) was related with extensive atrophy in previous studies using 11C-PiB, 18F-AV1451 and MRI data in healthy individuals.47,48 While the specific mechanisms behind the observed remote Aβ-atrophy relationship are still unclear, some of the associations may reflect distant effects of Aβ via prolonged deafferentation or increased tau aggregation in post-synaptic neurons connected by long-range white matter tracts. Here, MAPT is linked to Alzheimer disease.