reported the application of multifunctional liposomes co-loaded with paclitaxel and artemether in reducing the vasculogenic mimicry (VM) through induction of VM channels (composed of genotype-transformed tumor cells supplying nutrients to tumor cells and promoting their recurrence), and activation of apoptotic pathways for GSCs growth inhibition via downregulating expression of MMP-9, HIF-1α, and VEGF against invasive brain tumors (152). This evidence concerns the gene HIF1A and neoplasm.