1. Stimulating tumor-blood vessel formation and tumor metastasis by activating oncogenic genes e.g. Ras and MAPK, induction of hypoxia-inducible factor (HIF), PI3K/AKT and STAT-3 pathway via COX2 activation.2. Reduce the intratumoral population of M1 phenotypes of microglia/macrophages. This evidence concerns the gene STAT3 and neoplasm.