In another study on this drug, the integrin inhibitor AT-161 combined with 5-fluorouracil was injected into a mouse colon cancer liver metastasis model, and the combined application of ATN-161 and 5-fluorouracil significantly reduced tumor load as well as the extent of liver metastasis (P < 0.02), with significantly fewer hepatic tumor microvessels in the ATN-161 and ATN-161, 5-fluorouracil groups than in the control and 5-fluorouracil groups (P < 0.05). The gene discussed is TYR; the disease is malignant colon neoplasm.