It has also been shown that, by inhibiting integrin-linked kinase, the quinazoline-derived drug DZ-50 could significantly inhibit the metastasis of renal cancer by blocking the phosphorylation of AKT and FAK and subsequent cell survival, disrupting the adhesion of integrin α5, and killing tumor cells by exposure to extracellular matrix-associated tumor suppressors (65). This evidence concerns the gene PTK2 and neoplasm.