AKT1 and urinary bladder cancer: In bladder cancer, it was shown that integrin α5 and miR-328-3p expression were negatively correlated, and targeting integrin α5 inhibited bladder carcinogenesis by miR-328-3p could prevent bladder carcinogenesis and progression by targeting integrin α5 and inhibiting the downstream PI3K/AKT signaling pathway (86).