The results showed that compared with normal renal cells, the protein expression level of the two kinds of renal cell carcinoma cells was significantly higher than that of normal renal cells (786-O vs. HK-2, p = 0.036; 769-P vs. HK-2, p = 0.001) (Figures 9A, C), and the mRNA expression level of GSDMD in the two kinds of renal cell carcinoma cells was also significantly higher than that of normal renal cells (786-O vs. HK-2, p = 0.003; 769-P vs. HK-2, p = 0.015; 769-P vs. 786-O, p = 0.018) (Figure 9B). This evidence concerns the gene GSDMD and hereditary clear cell renal cell carcinoma.