Then, according to the information of 539 patients with ccRCC and 72 normal patients in TCGA database, we made the ROC curve (Figure 1B), and the results showed that the area under the curve (AUC) = 0.855, which showed that GSDMD has a good diagnostic significance for ccRCC and normal people, indicating that GSDMD is a potential diagnostic index for ccRCC. The gene discussed is GSDMD; the disease is nonpapillary renal cell carcinoma.