The results showed that there was a significant statistical difference (p < 0.001) between the two groups of specimens in the GSE53757 dataset of 72 normal and 72 tumor specimens (Figure 1D), and the ROC curve plotted based on the patient’s diagnosis and expression information also showed an AUC value of 0.859 (Figure 1E), indicating that the expression level of GSDMD has good significance for the classification and diagnosis of clear cell renal cell carcinoma. This evidence concerns the gene GSDMD and clear cell renal carcinoma.