As shown in the figure, epithelial–mesenchymal transition (EMT)-related molecules have a strong correlation with GSDMD in many tumors, as well as in ccRCC, where GSDMD is positively correlated with BCL3, IFITM3, STAT1, COL6A2, and RRAS and significantly negatively correlated with COL3A1, DDR2, HIF1A, PPIC, SDC2, SLC3A2, SPARC, GAS1, INHBA, LAMB1, and VLDLR (Figure 5). The gene discussed is HIF1A; the disease is nonpapillary renal cell carcinoma.