PI3 and nonpapillary renal cell carcinoma: Among the upregulated genes, in the MYC amplified MB PDX model, tumors with low OLIG2 expression are radiation sensitive and have fewer relapses, while tumors with high OLIG2 expression have high radiation resistance and a significantly increased probability of recurrence (28), a predictive signature based on the expression of PI3 could be an independent prognostic factor for ccRCC (29).