Among the upregulated genes, in the MYC amplified MB PDX model, tumors with low OLIG2 expression are radiation sensitive and have fewer relapses, while tumors with high OLIG2 expression have high radiation resistance and a significantly increased probability of recurrence (28), a predictive signature based on the expression of PI3 could be an independent prognostic factor for ccRCC (29). The gene discussed is OLIG2; the disease is nonpapillary renal cell carcinoma.