To investigate the latency of patient blasts harboring P2RY8::CRLF2 and high HMGN1 expression, NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice were engrafted with blasts from two ALL patients with P2RY8::CRLF2 and high HMGN1 expression (+21). Here, CRLF2 is linked to acute lymphoblastic leukemia.