Genes including the dual-specificity tyrosine phosphorylated and regulated kinase 1A (DYRK1A), ETS-related gene (ERG), ETS variant transcription factor 6 (ETV6), EBF transcription factor 1 (EBF1), and RUNX family transcription factor 1 (RUNX1) have been studied in ALL (12–18), while many more have been characterized in the context of AML, including the GATA-binding factor 1 (GATA1) (2), ubiquitin-specific peptidase 16 (USP16) (19), chromatin assembly factor 1 (CHAF1B) (20), and the microRNAs (mir99A and mir125b) (21, 22). Here, USP16 is linked to acute lymphoblastic leukemia.