Multivariable regression analyses showed that older age, male sex, tumor involvement of functional brain areas and deep brain structures, and alterations in CDK4, CDK6, and KMT5B were predictive of a decreased OS, while maximal surgical resection as compared to biopsy, treatment with the Stupp protocol, and MGMT promoter methylation was predictive of a prolonged OS (Table 2). This evidence concerns the gene CDK4 and neoplasm.