The most significant variant was LRP5L/rs78345670 (A→G) (19), which was also the top hit variant in GC (OR (95% CI) = 11.13 (3.32-37.32), P = 9.50×10-5) and CRC dataset [OR (95% CI) = 6.73 (2.62-17.30), P = 7.67×10-5]. This evidence concerns the gene LRP5L and colorectal carcinoma.