ABCC11/rs75797074 A allele showed protective effect with GI cancer risk in ESCC and CRC validation datasets while the results of ASSET meta-analysis indicated that it was a risk allele for GI cancer initiation [OR (95% CI) = 4.51 (2.62-7.77), PASSET = 5.23×10-8]. This evidence concerns the gene ABCC11 and esophageal squamous cell carcinoma.