Initial hyperproduction of Arc can be seen in epilepsy models with kainate, D1-receptor agonists, 4-Aminopyridine (4AP), Bicuculline (Bic), and Forskolin, pilocarpine, pentylenetetrazole, kindling, activation of mGluR, electroconvulsive stimulation (Also Arc mRNA and proteins are rapidly induced in the striatum after acute cocaine administration (80, 105–111). The gene discussed is ARC; the disease is epilepsy.