The most commonly investigated ALS genes, including superoxide dismutase (SOD1), chromosome 9 open reading frame 72 (C9orf72), TAR DNA-binding protein 43 (TDP43), and RNA binding protein fused in sarcoma (FUS), account for roughly 75% of familial ALS cases (Owens, 2017; Fang et al., 2022). Here, TARDBP is linked to amyotrophic lateral sclerosis.