Finally, we examined the expression of CD44, an astrocyte protein expressed in white matter astrocytes [see our preprint (Al Dalahmah et al., 2023)], astrocytes around large vessels, interlaminar astrocytes, and a subset of cortical astrocytes (Sosunov et al., 2014), as well as Clusterin (CLU), which is increased in neurodegenerative astrocytes in AD (Wojtas et al., 2020; Chen et al., 2021). This evidence concerns the gene CLU and Alzheimer disease.