In Drosophila, researchers used CRISPR-Cas9 to knock out tango14, the homologous gene of NUS1, and found that the lifespan of Drosophila was shortened, and cholesterol accumulation appeared in dopaminergic neurons, which confirms that this gene is associated with the occurrence of PD due to lipid metabolism abnormalities (Xue et al., 2022). The gene discussed is NUS1; the disease is Parkinson disease.