In a PD rat model with overexpression of SNCA (p. A53T), the significant rescue of α-synuclein overexpression, reactive astrogliosis, dopamine neuron degeneration, and Parkinsonian motor deficits was observed after knocking out SNCA gene using CRISPR Cas9 (Yoon et al., 2022). The gene discussed is SNCA; the disease is Parkinson disease.