Compared with the direct detection of biomarkers such as DJ-1, oxDJ-1, α-syn, and miRNA in the CSF or blood, exosome and microvesicle detection of these PD-related biomarkers has been reported to be more stable and reliable, and a better reflection of the PD disease state (Hartfield et al., 2012; Saito, 2017). The gene discussed is PARK7; the disease is Parkinson disease.