Higher gene expression of BIN1 found in AD brain has been found to increase trans-neuronal tau spreading (Chapuis et al., 2013; Calafate et al., 2016; Crotti et al., 2019), and to be associated with more pronounced tau pathology but not higher Aꞵ burden (Holler et al., 2014; Taga et al., 2020). Here, MAPT is linked to Alzheimer disease.