Another AD risk variant found in many GWAS is the gene BIN1 (i.e., bridging integrator 1), which encodes for a nucleoplasmic adaptor protein involved in many processes such as the regulation of neuronal excitability (Voskobiynyk et al., 2020), presynaptic vesicle release (De Rossi et al., 2020), and clathrin-mediated endocytosis (Calafate et al., 2016; Crotti et al., 2019). The gene discussed is BIN1; the disease is Alzheimer disease.