Although tau pathology spreads in a stereotypical pattern in AD (Braak and Braak, 1991), many studies have reported substantial individual variations in tau PET pattern, particularly in preclinical AD (Murray et al., 2011; Scholl et al., 2017; Ossenkoppele et al., 2020; Vogel et al., 2020; La Joie et al., 2021; Vogel et al., 2021; Frontzkowski et al., 2022; Young et al., 2022). Here, MAPT is linked to Alzheimer disease.