In a study using resting-state fMRI, DTI, and tau PET, it was reported that anatomical connections could predict 70% of the tau PET pattern observed in the brain of MCI and AD patients, whereas the functional and proximity connectivity models, respectively, explained 58 and 48% of the tangle pattern (Vogel et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.