These results are consistent with previous PET reports showing that APOE4 carriers across the entire AD continuum have a more medial temporal lobe-dominant pattern of tau burden even after controlling for amyloid accumulation (Livingston et al., 2017; Mattsson et al., 2018; Therriault et al., 2020; La Joie et al., 2021; Ossenkoppele et al., 2021a). This evidence concerns the gene APOE and Alzheimer disease.