MAPT and Alzheimer disease: By combining magnetoencephalography (MEG) to measure electrical activity in the brain with positron emission tomography (PET) to evaluate tau depositions at several stages of AD, a recent study by Schoonhoven and colleagues has shown that the functional connectivity model was most accurate (r = 0.58) compared to the structural (r = 0.45) and proximity model (r = 0.44) at predicting tau propagation in the preclinical stage of AD (Schoonhoven et al., 2022).