Moreover, there is a growing body of evidence suggesting that substantial inter-individual variabilities in the pattern and intensity of tau signal may be more common than previously expected in affected AD brain regions (Murray et al., 2011; Scholl et al., 2017; Hanseeuw et al., 2019; Jack et al., 2019; Lowe et al., 2019; Betthauser et al., 2020; Vogel et al., 2021). The gene discussed is MAPT; the disease is Alzheimer disease.