ESR1 and breast carcinoma: In women, the degree of tumoral differentiation may result from the interaction of GATA-3 with the BRCA1 gene, which cause the formation of protein complexes that suppress genes associated with the triple negative basal-like phenotype (ER−, PR−, HER-2−, and CK 5/6+ or CK14+) in breast carcinomas (45).