GATA3 and neoplasm: GATA-3 also alters the tumor microenvironment, as it interferes with angiogenesis, affects macrophages and lymphocytes within intratumoral inflammatory infiltrates, and acts in the regulation of the extracellular matrix via microRNA-29b, thereby inducing the expression of microRNA-29b both directly (binding to the GATA sites in the promoter) and indirectly (inhibiting the TGF-β and NF-κB pathways) (10, 15, 16).