C4B and cyclic hematopoiesis: Given that IL-6 is hypothesized to be a major factor contributing to the vicious cycle between hyperinflammation and clonal expansion in TET2 and DNMT3A CH (22–24), we asked whether the elevated levels of lung IL-6 in CH macaques resulted from or contributed to local lung expansion or persistence of CH mutant cells following SARS-CoV-2 infection.