DNMT3A and cyclic hematopoiesis: In this pilot study, we utilized our macaque models to ask whether disease severity and biologic characteristics following SARS-CoV-2 inoculation was enhanced in animals with either naturally occurring CH expanding post-autologous transplantation or engineered CH mutations in the DNMT3A or TET2 genes introduced via ex vivo editing followed by autologous transplantation, in comparison to similarly transplanted and conditioned middle-aged adult animals without CH mutations.