ACh regulatesthe memory and learning process and the cognitive performance.4 The selective and irreversible deficiency ofcholinergic functions results in the memory impairment in AD, andthis is what the cholinergic hypothesis proposes.5 Enhancement of ACh concentration in the brain, which compensatesthe cholinergic neurotransmitter deficit by inhibition of its hydrolyticenzymes (i.e., the cholinesterases), has provided the first generationof drugs for the treatment of AD. Here, BCHE is linked to Alzheimer disease.