LEP and Insulin resistance: The administration of fructose can fully replicate the metabolic syndrome, and lead to weight gain, visceral adiposity, insulin resistance, hypertriglyceridaemia, low HDL cholesterol, elevated blood pressure, fatty liver, microalbuminuria, hyperuricaemia and biomarkers of systemic inflammation (including low adiponectin, elevated leptin and elevated high-sensitivity C-reactive protein) [67].