They also found that disorders such as liver fibrosis, ovarian carcinoma, breast carcinoma, lung cancer, liver carcinoma, and prostate cancer might have correlation with gastric adenocarcinoma through certain genes, including mt2a, fn1, hgf, col1a1, col1a2, and mmp2. In their study, overexpression of signaling pathways, including extracellular matrix organization, cell division, and cell cycle, as well as downregulation of ion transport and digestion pathways were also indicated. This evidence concerns the gene COL1A1 and hepatocellular carcinoma.