It has been observed in neuroblastoma that the presence of NNMT could meaningfully reduce the death of SH-SY5Y cells, and the effects of NNMT were positively correlated with the elevated intracellular ATP content, ATP/ADP ratio, and CxI activity, as well as a decrease in the degradation of the NDUFS3 subunit of CxI [43]. Here, NDUFS3 is linked to neuroblastoma.