Rac1 activity is required for mature invadopodia formation and/or ECM degradation in some cancer cell lines, while Rac1 regulates invadopodia disassembly at the final stage in others (Goicoechea et al., 2017; Moshfegh et al., 2014; Nakahara et al., 2003; Nascimento et al., 2011; Pignatelli et al., 2012). This evidence concerns the gene RAC1 and cancer.