RAC1 and breast cancer: The details of whether Rac1 participates in the emergence of invadopodia at the early stage are still unclear (Rivier et al., 2021), but our time-lapse imaging data may suggest that Rac1 mediates invadopodia emergence and FilGAP inactivates Rac1 at this stage, resulting in suppression of invadopodia formation in breast cancer cells.