Cannabidiol shows promise as a treatment for cocaine use disorder, consistent with our observation that higher expression of Trpv2 is associated with lower cocaine IVSA.67Trpv2 knockout mice have been created and show macrophage and mechanical nociception phenotypes.68-70 These mice would be an attractive reagent to test the role of Trpv2 in cocaine IVSA. This evidence concerns the gene TRPV2 and cocaine use disorder.