In this study, we identified that PirB/LILRB2 were expressed in hepatic macrophages and bound with their NASH-associated ligand (ANGPTL8) to trigger the recruitment of macrophages to the liver, providing evidence that the LILRB2/PirB-ANGPTL8 axis could be a pathogenic driver of NASH pathogenesis and fibrogenesis. Here, ANGPTL8 is linked to metabolic dysfunction-associated steatohepatitis.