We found that glioma-derived exosomes (GDEs) increased XBP1s expression in human BM-MSCs and that exosomes isolated from DICER knockdown glioma (GDEs-DICER-KD) still increased XBP1s expression in BM-MSCs, suggesting that glioma exosomes can upregulate XBP1s expression in human BM-MSCs in an miRNA-independent manner (Fig. S4C). The gene discussed is DICER1; the disease is central nervous system cancer.