NT5E and central nervous system cancer: Furthermore, MDSCs derived from the GA-MSC group had the strongest ability to suppress T-cell proliferation, and the T-cell-suppressive function of MDSCs could be inhibited by a CD73 inhibitor (M8386, Sigma‒Aldrich) (Fig. S1D), indicating that GA-MSCs promoted the formation of an immunosuppressive microenvironment in glioma by upregulating CD73 expression on MDSCs.