In this study, TP5335,36 and PDE10A mutations (Fig. 2C), as well as enrichment of pathways such as WNT– β-catenin , TGF-β, and YAP/Hippo signaling pathways37 (Fig. 2D), led to the high frequency of low-cytotoxicity immunophenotypes and the tendency of tumor immune evasion in high-risk group. Here, TGFB1 is linked to neoplasm.