Risk scores were positively correlated with genes such as MCM6, POLD3, MSH6, and MSH2 (Fig. 5C), but negatively correlated with 14 steps in Cancer-Immunity Cycle (Fig. 5D), including initiation activation, T cell recruitment, CD4+ T cell recruitment, CD8+ T cell recruitment, Th1 cell recruitment, and NK cell recruitment. This evidence concerns the gene POLD3 and cancer.