SYP and diabetes mellitus: Western blotting of synaptic proteins showed that diabetes reduced the expression of the presynaptic protein Synaptophysin (SYP) and the postsynaptic protein PSD 95, while overexpression of SIRT3 promoted the expression of SYP and PSD 95, although increased expression of PSD95 failed to reach statistical significance (see Additional file 2: Fig. S1a–c).