Mechanistically, FUS regulated the biogenesis of circEHD2, then circEHD2 interacted with YWHAH in the nucleus of RCC cells, while YWHAH functioned as a bridge to recruit circEHD2 and YAP to the SOX9 promoter, thus sustaining activated SOX9 to promote RCC cell growth. This evidence concerns the gene YWHAH and renal cell carcinoma.