UBE3C and nonpapillary renal cell carcinoma: CircPOLR2A accelerates ccRCC cell invasion and angiogenesis by binding to UBE3C and PEBP1 proteins, then the UBE3C/circPOLR2A/PEBP1 protein -RNA ternary complex regulates the ERK signaling pathway, resulting in the progression of ccRCC [15].