TYR and albinism: Mutations in tyrosinase (TYR) have been shown to cause albinism in many mammalian species, including cattle (Schmutz et al. 2004), water buffalo (Damé et al. 2012), cats (Imes et al. 2006), humans (Stenson et al. 2003; Kamaraj and Purohit 2014), and mice (Hubbard et al. 2010).