Besides, we also compared the expression differences of the identifiedmarkers in TCGA-COAD cohort (Figure 3H), andfound that only REG1A and CD16 were significantlydifferential expressed between LCC and RCC samples, which may indicate that DEGsobtained from bulk RNA-seq data cannot reflect the true expression of genes indifferent cell types. This evidence concerns the gene REG1A and leukoencephalopathy with calcifications and cysts.