<h4>Background</h4>The current study attempted to investigate the role of transcription factor c-fos in the development of premature ovarian insufficiency (POI) as well as the underlying mechanism involving the MALAT1/miR-22-3p/STAT1 ceRNA network.<h4>Methods</h4>Bioinformatics analysis was performed to extract POI-related microarray dataset for identifying the target genes. Here, STAT1 is linked to premature menopause.