To further understand whether CCHE1 modulated LDHA phosphorylation via regulating FGFR1, melanoma cells were treated with FGFR1 inhibitor PD-166866 and the data showed that, the enhanced LDHA phosphorylation by CCHE1 was abolished in the presence of PD-166866 (Fig. 5C). This evidence concerns the gene CCEPR and melanoma.