In the early stage of CRLM, the adherence of disseminated cancer cells to KCs prompts KCs to capture and phagocytose the cancer cells and release TNF-α, interleukin-1α (IL-1α) and IL-1β, thus reducing the metastasis of colon cancer cells to the liver [94, 95]. This evidence concerns the gene TBCE and malignant colon neoplasm.