CXCL8 and colorectal carcinoma: (2) Extravasation and preangiogenic phase: CRC cells relocate to the space of Disse, thus recruiting stromal cells, including hepatic stellate cells (HSCs) that are responsible for the secretion of fibronectin and collagen to form a framework for neovascularization [56, 57] and portal tract fibroblasts, which generate IL-8 to promote invasion and angiogenesis [58].