Among the 24 DEGs, 4 genes (CASP1, CASP8, IL18, and TP53) were upregulated in GSE30528 (Kidney tissue samples were microdissected glomeruli from DN patients, the same as GSE96804), 10 genes (CASP1, CASP3, CASP4, CASP8, NLRP1, PLCG1, NAIP, ZBP1, IRF1 and TP53) were upregulated and CASP9 was downregulated in GSE142025 (Kidney tissue samples were from advanced DN patients) (Fig. 3A, B). This evidence concerns the gene ZBP1 and liver dysplastic nodule.