For IL-6, Aβ[ −] RHI/TES had higher concentrations than controls (p < 0.001, d = 1.1), Aβ[ +] RHI/TES (p = 0.004, d = 1.2), and patients with AD (p < 0.001, d = 1.1), while Aβ[ +] RHI/TES did not significantly differ from controls (p = 0.96, d < 0.10) or patients with AD (p = 0.91, d < 0.10). This evidence concerns the gene IL6 and Alzheimer disease.