When stratifying patients with RHI/TES based on amyloid status (Fig. 3), Aβ[ +] RHI/TES had higher plasma GFAP than controls (p = 0.01, d = 0.88) but did not differ from patients with AD (p = 0.26, d = 0.38), while Aβ[ −] RHI/TES did not differ from controls (p = 0.20, d = 0.40) and had lower plasma GFAP than patients with AD (p = 0.003, d = 0.86). The gene discussed is GFAP; the disease is Alzheimer disease.