The IL-11 was first recognized in 1990 as a protein factor that promoted a murine plasmacytoma cell line, initially assumed to be dependent on IL-6 [36].The pleiotropic nature of IL-11 soon became apparent, as it was also characterized as a factor emanating from a bone marrow-derived cell line culture that impeded adipogenesis in preadipocytes [37]. This evidence concerns the gene IL11 and plasmacytoma.