The most recent meta-analysis, comparing an ovarian reserve test-based algorithm (basal FSH, AFC and AMH) with no algorithm, found a reduction of the likelihood of moderate or severe OHSS [4 RCTs; odds ratio (OR) 0.58, 95% CI 0.34 to 1.00, n = 2823; I2 = 0%] with the use of the ovarian reserve test-based algorithm [40]. Here, BRD2 is linked to ovarian hyperstimulation syndrome.