A systematic review of RCTs with meta-analysis analyzed the effects on OHSS incidence of r-LH combined with r-FSH in ovarian stimulation in comparison with r-FSH alone, demonstrating no significant effect (6 RCTs; OR 0.38, 95% CI 0.14 to 1.01, n = 2,178; I2 = 10%) [63]. Here, BRD2 is linked to ovarian hyperstimulation syndrome.