Key demographic and clinical factors include young age, polycystic ovary syndrome (PCOS) [31], ovulatory disorders [3], low body mass index (BMI) [32], history of previous OHSS [13], genetics factors [33] In terms of ovarian reserve markers, serum anti-Müllerian hormone (AMH) level above 3.36 ng/mL (with over 90% sensitivity) [34] and late follicular phase serum estradiol levels above 3,500 pg/mL [13, 35] can predict the risk of OHSS. The gene discussed is AMH; the disease is polycystic ovary syndrome.