Furthermore, TRF-33-q1q89p9l842205was found toact as a tumour suppressor in LSCC, and PIK3CD was identified as a direct target of TRF-33-q1q89p9l842205 in regulating LSCC progression.Collectively, these findings suggest that TRF-33-q1q89p9l842205 is a potential biomarker for LSCC and possibly acts as a tumour suppressor and therapeutic candidate by directly targeting PIK3CD [46]. Here, PIK3CD is linked to neoplasm.