CLU and Alzheimer disease: SNPs in CLU previously identified in AD GWAS [18] [rs11136000, rs9331896, rs2279590 in linkage disequilibrium (LD; r2 > 0.85) and rs9331888 (r2 with rs11136000 = 0.26)] were tested for impact on plasma clusterin by comparing levels in carriers of the minor alleles at rs11136000 (T/C, used as surrogate for SNPs in LD) and rs9331888 (G/C) with carriers of the major allele.