CLU and Alzheimer disease: Compared to controls, early and late AD cases had significantly higher levels of plasma C1q (149.8 μg/ml EOAD, 142.9 μg/ml LOAD, 107.9 μg/ml control; p < 0.001, Fig. 1A) and clusterin (224.6 μg/ml EOAD, 205.8 μg/ml LOAD, 195.8 μg/ml control, p < 0.005; Fig. 1B).