Interestingly, a significant association was found between MAL2 expression and the negatively infiltrating level of eosinophils and plasmacytoid dendritic cells [11], and the depletion of MAL2 in breast tumor cells significantly enhanced tumor-infiltrating CD8+T cell cytotoxicity and suppressed breast tumor growth, suggesting that MAL2 is a potential immunotherapy target for the treatment of BC [12]. This evidence concerns the gene MAL2 and breast neoplasm.