MAL2 and breast cancer: As shown in Fig. 7B, BC cells exhibited increased migration and invasion ability in the MAL2 silencing + SKL2001 group as compared to the MAL2 silencing group alone (P < 0.05)., Furthermore, the EMT-associated proteins were detected in MDA-MB-231 and MCF-7 cells after SKL2001 treatment for 24 h.