In OLP lesions, ROS exacerbate inflammatory conditions linked to immunological pathways through the activation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex that regulates proinflammatory gene transcription, such as interleukin 2 (IL-2), tumor necrosis factor-alpha (TNF-α), MHC class 1 gene, and IL-2 receptor gene [2, 30]. Here, NFKB1 is linked to oral lichen planus.